Search results for "target [deuteron]"
showing 10 items of 159 documents
DOS vs TOS. Estrategias complementarias en la cobertura del espacio químico
2017
Las moléculas pequeñas siempre han sido de interés en química debido a su capacidad para ejercer poderosos efectos sobre las funciones de las macromoléculas presentes en los sistemas vivos. El estudio de estas sutiles interacciones es fundamental para el diseño de nuevos fármacos. Sin embargo, a pesar de que el nivel de inversión en investigación y desarrollo aplicado al descubrimiento de nuevos fármacos ha incrementado drásticamente, el números de nuevos compuestos no ha aumentado. En este contexto, la búsqueda de nuevas estructuras que posean una relevante actividad terapéutica permanece como objetivo principal en química farmacéutica. La evolución de los métodos sintéticos en química org…
Tracking the Preferences of Users Using Weak Estimators
2011
Published version of am article from the book:AI 2011: Advances in Artificial Intelligence. Also available from the publisher on SpringerLink:http://dx.doi.org/10.1007/978-3-642-25832-9_81 Since a social network, by definition, is so diverse, the problem of estimating the preferences of its users is becoming increasingly essential for personalized applications which range from service recommender systems to the targeted advertising of services. However, unlike traditional estimation problems where the underlying target distribution is stationary, estimating a user’s interests, typically, involves non-stationary distributions. The consequent time varying nature of the distribution to be trac…
Ar veselību saistītas metaforas rakstos par ekonomiskiem jautājumiem
2018
Konceptuālo metaforu teorija izsaka iespējamību par universālu metaforu eksistenci dažādās valodās. Bakalaura darba mērķis bija identificēt veselības metaforas rakstos par ekonomikas jautājumiem angļu un latviešu valodā un noskaidrot kā tās konceptualizē ar ekonomiku saistītas problēmas. Pētījums ir balstīts uz konceptuālās metaforu teorijas. Metaforu identifikācijai kontekstā tika izmantota deduktīvā metode un izpētīja tās no kvalitatīvās un kvantitatīvās perspektīvas. Tika atklāts, ka visbiežāk sastopamākās veselības metaforas bija problēma ir slimība/traucējumi un uzlabojums ir ārstēšana/atveseļošanās ar metaforiskajām izpausmēm ‘vājums’ un ‘atveseļošanās’. Rezultāti atklāja, ka veselība…
Metaforu lietojums mārketinga blogos
2016
Šī pētījuma mērķis bija analizēt metaforu veidus, kas ir izmantoti mārketinga blogos, noteikt to izmantošanas mērķi mārketinga blogu ierakstos un noteikt avota un mērķa domēnus, kurus var atrast identificētajās metaforās. Pētījuma metode bija diskursa analīze. Rezultāti liecina, ka visplašāk izmantotais metaforu veids blogu ierakstos ir konceptuālās metaforas; kam seko “tradicionālās” metaforas, taču tās izmanto retāk. Mērķa domēni, kas tiek skaidroti, izmantojot metaforas, ir saistīti ar mārketinga terminoloģiju; avotu domēni, kas visplašāk tiek izmantoti paskaidrojumam ir daba, dzīvnieku/cilvēku uzvedība un ceļojums. Metaforas izmanto mārketinga blogos, lai izskaidrotu konkrētu mārketinga…
Anticancer therapy-induced vascular toxicity: VEGF inhibition and beyond
2017
Cardiotoxicity induced by chemotherapeutic agents and radiotherapy is a growing problem. In recent years, an increasing number of new drugs with targeted action have been designed. These molecules, such as monoclonal antibodies and tyrosine kinase inhibitors, can cause different type of toxicities compared to traditional chemotherapy. However, they can also cause cardiac complications such as heart failure, arterial hypertension, QT interval prolongation and arrhythmias. Currently, a field of intense research is the vascular toxicity induced by new biologic drugs, particularly those which inhibit vascular endothelial growth factor (VEGF) and its receptor (VEGF-R) and other tyrosine kinases.…
Predicting efficacy and toxicity in the era of targeted therapy: focus on anti-EGFR and anti-VEGF molecules
2011
The treatment of solid malignancies includes various target drugs, such as monoclonal antibodies and tyrosine kinase inhibitors, which exert their effect alone or in combination with chemotherapy. The main part of these molecules have a target on proteins of EGFR and VEGF pathways. The particular toxicity profile and the financial impact, deriving from the application of these agents in cancer treatment, prompted a lot of researches to define predictive factors of their efficacy. Various biomarker were identified among the components of the targeted pathways. However just few studies allowed to identify specific factors to predict the toxicity of these drugs. In this review EGFR and VEGF-re…
Anti-inflammatory Function of High-Density Lipoproteins via Autophagy of IκB Kinase
2015
Background & Aims: Plasma levels of high-density lipoprotein (HDL) cholesterol are frequently found decreased in patients with inflammatory bowel disease (IBD). Therefore, and because HDL exerts anti-inflammatory activities, we investigated whether HDL and its major protein component apolipoprotein A-I (apoA-I) modulate mucosal inflammatory responses in vitro and in vivo. Methods: The human intestinal epithelial cell line T84 was used as the in vitro model for measuring the effects of HDL on the expression and secretion of tumor necrosis factor (TNF), interleukin-8 (IL-8), and intracellular adhesion molecule (ICAM). Nuclear factor-κB (NF-κB)-responsive promoter activity was studied by …
DIAGSOL : development of a new functional marker of exposure to herbicides B-triketones in an agricultural soil
2020
Numerous herbicides target an enzyme found not only in weeds but also in « non-target organisms » such as microorganisms. This proof-of-concept study aims to use microbial gene encoding the targeted enzyme or the targeted enzyme itself as a marker for herbicide exposure in soils. The hppd gene and the encoded enzyme (HPPD; 4-hydroxyphenylpyruvate dioxygenase), targeted by B-triketone herbicides, are the subject of this study. In silico analyses reveal that the hppd gene is spread out in all bacterial phyla. Primers specific to this gene were designed. This primer pair is used to measure the abundance, the composition and the diversity of the hppd bacterial community in soil microcosms expos…
Conséquences de l’utilisation de variétés de tournesol tolérantes aux herbicides sur la flore des agrosystèmes
2022
The farming practices associated with the use of sunflower herbicide-tolerant varieties (HTVs) have raised concerns among public authorities, who have recommended monitoring the potential effects of HTVs on biodiversity. In this context, at the scale of three French departments, the vegetation of 239 sunflower fields and their margins was studied between 2017 and 2019. This lower weed diversity can be attributed to shorter crop rotations and higher herbicide use. Admittedly, the higher densities of A. artemisiifolia observed in plots with HTVs are the cause of the use of these varieties rather than the consequence of these practices. However, these practices do not seem to solve the problem…
The Metabolic Syndrome and Its Relationship to Hypertensive Target Organ Damage
2007
High blood pressure is often associated with various metabolic abnormalities, including abdominal obesity, dyslipidemia, elevated plasma glucose, and insulin resistance, which are the main features of the metabolic syndrome. The metabolic syndrome is extremely common worldwide. This high prevalence is of considerable concern because several studies suggest that the metabolic syndrome carries an increased risk for cardiovascular events. Several lines of evidence seem to indicate that the metabolic syndrome is associated with an increased prevalence of preclinical cardiovascular and renal changes, such as left ventricular hypertrophy, microalbuminuria, impaired aortic elasticity, and early ca…